CMST-Action CM1303

Welcome to the project website for COST Action CM1303.

The purpose of this site is to inform the scientific community about our work and activities. 
We promote collaboration and co-operation in the analysis of enzymatic systems in vivo, the development and discovery of new biocatalysts, and their assembly in vitro into novel synthetic metabolic pathways.

COST Committee of Senior Officials Approval date 16/05/2013
Entry into force 22/06/2011
Start of Action 20/11/2013
End of Action 19/11/2017



Systems Biocatalysis

is a new approach consisting of organizing enzymes in vitro to generate an artificial metabolism for synthetic purposes.

The strategy of this key new platform deals with the analysis of enzymatic systems in vivo, the development and discovery of new biocatalysts, and their assembly in vitro into novel synthetic metabolic pathways. This network aims at the controllable construction of metabolic pathways for the efficient synthesis of valuable chemical products. Tasks involved are the discovery of new biocatalysts, the optimization of their function, mutual compatibility and regulation, and the construction of a continuous flux for high efficiency. These tasks require research in various disciplines, as well as in molecular and engineering aspects of whole synthetic reaction sequences. Therefore, this multidisciplinary Action is organized by an innovative grid WG structure. The latter will interface vertical thematic pillars with horizontal technology bridges, to foster a profound integration of the ERA. The new collaborative research network will develop innovative methods for the discovery, design, optimization, and use of novel biocatalytic modules towards a plug-and-play enzymatic toolbox concept. This platform will be instrumental for the training of the next generation of researchers in cutting-edge technologies and for the rapid translation of results into value creation by European industries.


COST (European Cooperation in Science and Technology) is a pan-European intergovernmental framework. Its mission is to enable break-through scientific and technological developments leading to new concepts and products and thereby contribute to strengthening Europe's research and innovation capacities. It allows researchers, engineers and scholars to jointly develop their own ideas and take new initiatives across all fields of science and technology, while promoting multi- and interdisciplinary approaches. COST aims at fostering a better integration of less research intensive countries to the knowledge hubs of the European Research Area. The COST Association, an International not-for-profit Association under Belgian Law, integrates all management, governing and administrative functions necessary for the operation of the framework. The COST Association has currently 36 Member Countries.

Contact details

Chair of the Action:
Prof Stefano Servi

Vice Chair of the Action:
Prof Isabella Arends

STSM Coordinator:
Dr Sergio Riva

Grant Holder:
Technische Universität Darmstadt

Grant Holder Scientific

Prof Wolf-Dieter Fessner

Science Officer (COST Office):
Dr Lucia Forzi

Administrative Officer (COST

Ms Svetlana Voinova


MC Chair Progress report 1: July 2015

MC Chair Progress report 2: June 2016

MC Chair Final report

Rapporteur Review



Memorandum of Understanding
MoU - download as PDF

COST Vademecum
Vademecum - download as PDF



COST is supported by the EU Framework Programme Horizon 2020




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This website is supported by COST (European Cooperation in Science and Technology)